Acep Oral Suspension 120 mg/5 ml

Acep Oral Suspension is a trusted oral suspension containing Paracetamol (120 mg/5 ml), manufactured by Zenith Pharmaceuticals Ltd. Priced at ৳35.00 per unit, it offers rapid relief from fever, pain, and inflammation. This formulation is particularly suitable for children and adults who prefer liquid medications.

This Paracetamol-based medicine effectively treats multiple conditions including post-vaccination pain, arthritis, menstrual cramps, and postoperative discomfort. Its anti-pyretic properties help regulate body temperature during infections like influenza. The suspension form ensures accurate dosing for pediatric patients.

The pharmacological action involves inhibiting prostaglandin synthesis through COX enzyme pathways in the CNS. Unlike NSAIDs, Acep Oral Suspension causes fewer gastric side effects, making it safer for prolonged use. However, alcohol consumption may increase hepatotoxicity risks.

• Child Dosage: 1-2 teaspoons (3-4 times daily) for ages 1-5 years
• Adult Dosage: 4-8 teaspoons every 4-6 hours

Reported side effects include rare allergic reactions and skin rashes. Patients with liver disorders should consult doctors before use. Store in cool, dry places away from children. The Zenith Pharmaceuticals product maintains strict quality standards for optimal therapeutic outcomes.

Suspension dosage: 1-2 teaspoons for 1-5 years, 2-4 teaspoons for 6-12 years, 4-8 teaspoons for adults (every 4-6 hours). Max daily dose 4 grams. Reduce dose in renal/hepatic impairment. Can be taken with/without food. Consult doctor if fever persists beyond 3 days.

Side effects of Acep are usually mild, though haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.

Pregnancy Category B. Safe during lactation in therapeutic doses. Avoid prolonged use without medical supervision.

Monitor hepatic/renal function in high-risk patients. Avoid concurrent use of other paracetamol-containing products. Seek medical advice if symptoms persist beyond 3 days (fever) or 5 days (pain).

Reduce dose in elderly/hepatic/renal impairment. Pediatric dosing based on age/weight. Use lowest effective dose in pregnancy.

Liver damage is possible in adults who have taken 10 g or more of Acep. Ingestion of 5 g or more of Acep may lead to liver damage if the patient has following risk factors: If the patient is on long term treatment with Carbamazepine, Phenobarbitone, Phenytoin, Primidone, Rifampicin, St John’s Wort or other drugs that induce liver enzymes, or regularly consumes Ethanol in excess of recommended amounts, or is likely to be Glutathione deplete e.g. eating disorders, cystic fibrosis, HIV infection, starvation, cachexia.

Symptoms: Symptoms of Acep overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported. Immediate treatment is essential in the management of Acep overdose. Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma Acep concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of Acep. However, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral Methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be discussed with the NPIS or a liver unit.