Aceta One Tablet 1000 mg

Aceta One Tablet is a widely used analgesic containing 1000 mg Paracetamol, manufactured by Biopharma Limited. This tablet formulation effectively treats fever, headaches, post-vaccination pain in children, and various inflammatory conditions. Priced at ৳2.25 per unit, it offers affordable relief across Bangladesh.

The medication inhibits prostaglandin synthesis via COX enzymes in the CNS, providing rapid pain relief. Unlike NSAIDs, it causes fewer gastrointestinal side effects, making it safer for long-term use. Always follow dosage guidelines to avoid liver complications.

Dosage Guidelines:

• Adults: 1-2 tablets every 4-6 hours (max 8 tablets/day)
• Children (6-12 years): ½-1 tablet 3-4 times daily

Store in a cool, dry place away from children. Avoid concurrent use with alcohol or barbiturates, as it may increase hepatotoxicity. Pregnant/lactating women should consult doctors despite its safety profile.

Common alternatives include Aceta 500 mg and Aceta Extend 665 mg. For precise dosing of syrups/suppositories, consult healthcare providers. Overdose requires immediate N-acetylcysteine treatment to prevent liver failure.

Tablet: Adults 1-2 tablets every 4-6 hours (max 8/day). Children (6-12 years): 0.5-1 tablet 3-4 times daily. Dose reduction needed in renal/hepatic impairment. Take with/without food. Do not exceed 10 days without medical advice.

Side effects of Aceta One are usually mild, though haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.

Pregnancy Category B. Safe during lactation at therapeutic doses. Consult physician for prolonged use.

Monitor liver function in chronic alcoholics, malnourished patients. Hepatic/renal impairment requires dose adjustment.

Pediatric: Contraindicated in neonates <3 months. Geriatric: Adjust dose for age-related renal decline. Hepatic/renal impairment: Reduce dose by 50%.

Liver damage is possible in adults who have taken 10 g or more of Aceta One. Ingestion of 5 g or more of Aceta One may lead to liver damage if the patient has following risk factors: If the patient is on long term treatment with Carbamazepine, Phenobarbitone, Phenytoin, Primidone, Rifampicin, St John’s Wort or other drugs that induce liver enzymes, or regularly consumes Ethanol in excess of recommended amounts, or is likely to be Glutathione deplete e.g. eating disorders, cystic fibrosis, HIV infection, starvation, cachexia.

Symptoms: Symptoms of Aceta One overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported. Immediate treatment is essential in the management of Aceta One overdose. Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma Aceta One concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of Aceta One. However, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral Methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be discussed with the NPIS or a liver unit.