Aciphin IV Injection 2 gm/vial

Aciphin Injection 2gm/Vial is a potent third-generation cephalosporin antibiotic containing Ceftriaxone Sodium. Manufactured by ACI Limited, this IV/IM formulation treats bacterial infections like pneumonia, meningitis, sepsis, and gonorrhea. Priced at ৳320.00 per vial, it offers broad-spectrum efficacy against Gram-positive and Gram-negative bacteria with once-daily dosing convenience.

Aciphin Injection’s pharmacology involves inhibiting bacterial cell wall synthesis, making it resistant to beta-lactamase enzymes. Its prolonged half-life (6–9 hours) allows 24-hour dosing. The drug is excreted via urine (40–65%) and bile, ensuring dual elimination. Protein binding exceeds 95%, enhancing tissue penetration for complex infections.

Indications include respiratory, skin, urinary tract, and bone/joint infections. It’s also used for surgical prophylaxis. Adults typically receive 1–2g daily, while children require 50–75mg/kg. Severe infections may need up to 4g/day. For gonorrhea, a single 250mg IM dose suffices. Treatment continues 48 hours post-symptom resolution, often spanning 4–14 days.

Common side effects include diarrhea, rash, and elevated liver enzymes. Rare risks include thrombocytopenia and seizures. Avoid use in penicillin-allergic patients. Pregnant/nursing women should consult doctors due to limited safety data. Store below 30°C, shielded from light. Explore alternatives like IV Injection formulations for tailored therapy.

Adults: 1-2g daily IV/IM (max 4g). Children: 50-75 mg/kg daily (max 2-4g). Gonorrhea: 250mg single dose. Surgical prophylaxis: 1g IV pre-op. Continue treatment 2 days post-symptom resolution, typically 4-14 days duration.

Aciphin is generally well tolerated. A few side effects such as gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis; cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme; hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia; hepatic reactions including elevations of SGOT or SGPT, bilirubinemia; CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness were reported. Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes.

Pregnancy Category B. Use only if clearly needed. Excreted in breast milk – use with caution during lactation.

Monitor for anaphylaxis. Administer IV slowly. Long-term use requires gallbladder ultrasound and blood monitoring. Manufactured by ACI Limited, use under medical supervision.

Contraindicated in neonates. Dose adjustment may needed in hepatic/renal impairment. Elderly can use standard doses.

There is no specific antidote. Treatment of overdosage should be symptomatic.