Aciphin IM Injection 250 mg/vial

Aciphin Injection is a potent third-generation cephalosporin antibiotic containing Ceftriaxone Sodium 250 mg/vial. Manufactured by ACI Limited, this broad-spectrum IM injection effectively treats respiratory, urinary, skin, and bone infections at ৳100.30 per vial.

This Ceftriaxone Sodium formulation works by inhibiting bacterial cell wall synthesis. Its 6-9 hour half-life allows once-daily dosing for adults (1-2g) and pediatric patients (50-75mg/kg). Maximum daily doses reach 4g for severe meningitis and 2g for children.

Key indications include pneumonia, gonorrhea, bacterial sepsis, and surgical prophylaxis. Storage requires cool, dry conditions below 30°C. Common side effects involve gastrointestinal distress and skin reactions, while rare cases report hematologic changes.

Priced at ৳100.30 per unit, Aciphin shows 95% plasma protein binding with dual renal/hepatic elimination. Contraindicated in penicillin-allergic patients, it requires medical supervision during pregnancy. Always complete prescribed courses despite symptom resolution.

Adults: 1-2g daily IV/IM. Pediatric: 50-75 mg/kg/day. Meningitis: 100 mg/kg. Gonorrhea: 250 mg single dose. Treatment duration 4-14 days. Administer IM injections slowly over 2-4 minutes.

Aciphin is generally well tolerated. A few side effects such as gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis; cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme; hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia; hepatic reactions including elevations of SGOT or SGPT, bilirubinemia; CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness were reported. Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes.

Pregnancy safety unestablished. Use caution during lactation. Reports of neonatal bloody stools.

Keep epinephrine ready for anaphylaxis. Monitor liver enzymes during prolonged use. Check gallbladder sludge. Follow ACI Limited prescribing guidelines.

No dose adjustment in renal impairment. Use cautiously in hepatic dysfunction. Reduced clearance in elderly.

There is no specific antidote. Treatment of overdosage should be symptomatic.