Aclene Cream 0.1%

Aclene Cream (Generic: Adapalene) is a topical retinoid medication manufactured by Drug International Ltd. Formulated as a 0.1% cream, it treats acne by regulating skin cell turnover and reducing inflammation. Priced at ৳60.20 per tube, it offers an affordable solution for persistent facial, chest, or back acne.

The cream works by binding to retinoic acid receptors, normalizing follicular epithelial cell growth. Clinical studies show it effectively prevents microcomedone formation. Apply a thin layer daily on affected areas at bedtime. Avoid concurrent use with drying agents like sulfur or salicylic acid-based products to prevent irritation.

Common side effects include erythema, itching, and peeling – typically diminishing after 4 weeks. Not recommended for children under 12. Pregnant women should use it only if benefits outweigh risks. Store below 25°C in airtight containers. Explore other cream formulations for comparative analysis.

Key advantages include:

• Targeted action on acne pathogenesis
• Minimal systemic absorption
• Cost-effective compared to similar retinoids

Apply 0.1% cream once daily at bedtime to affected areas. The 0.3% formulation may be used on full face. Not recommended for children under 12. Continuous use for 8-12 weeks required for optimal results. Cleanse skin before applying cream.

Erythema, scaling, dryness, pruritus, burning sensation, skin irritation, stinging unburn, acne flares, etc. are commonly seen during the first month of therapy but usually lessen with continued use of the medication.

Pregnancy Category C: Use only if potential benefit justifies risk. No data on lactational excretion; precaution advised during breastfeeding. Limit application to skin areas.

Use broad-spectrum sunscreen (SPF 30+). Avoid application on wounds/abrasions. Monitor skin sensitivity during menstruation. Discontinue if severe irritation occurs.

No dosage adjustment needed in hepatic/renal impairment. Pediatric use (<12 years) not established. Geriatric patients may have increased skin fragility.