Aclobet Ointment 0.05%

Aclobet Ointment is a topical corticosteroid containing Clobetasol Propionate 0.05%, manufactured by ACME Laboratories Ltd. Priced at ৳150.00 per unit, this ointment treats inflammatory skin conditions like psoriasis, lichen planus, and recalcitrant dermatoses. It works by reducing inflammation, itching, and skin cell proliferation through potent anti-inflammatory actions.

This high-potency steroid should be applied twice daily in thin layers to affected areas. Treatment duration is typically limited to 2 weeks for adults and 5 days for children. Maximum weekly use must not exceed 50 grams. Patients should avoid occlusive dressings unless directed by physicians for resistant cases like hyperkeratosis.

Key pharmacological actions include inhibition of mast cell activity, cytokine production, and arachidonic acid metabolism. While effective, prolonged use may cause skin thinning, striae, or systemic absorption leading to hypercorticism. Rare side effects include pigment changes and hypersensitivity reactions requiring immediate discontinuation.

Special precautions apply for pregnancy, lactation, and CYP3A4 inhibitor drug interactions. Store below 30°C, protected from light and moisture. As Bangladesh’s trusted ACME Laboratories product, Aclobet remains essential in managing stubborn dermatological conditions when milder steroids fail.

Apply thin layer twice daily for adults and children above 1 year. Limit use to 2 weeks (max 50g/week). For children, restrict to 5 days. Scalp solution: 1-2 applications daily. Shampoo: Leave for 15 minutes before rinsing. Use occlusive dressing only under medical supervision.

• As with other topical corticosteroids prolonged use of large amounts, or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercorticism.
• Prolonged and intensive treatment with a highly active corticosteroid preparation may cause local atrophic changes in the skin such as thinning, striae and dilatation of the superficial blood vessels, particularly when occlusive dressings are used or when skin folds are involved.
• In rare instances, treatment of psoriasis with corticosteroids (or its withdrawal) is thought to have provoked the pustular form of the disease.
• There are reports of pigmentation changes and hypertrichosis with topical steroids. Aclobet is usually well tolerated, but if signs of hypersensitivity appear, application should be stopped immediately. Exacerbation of symptoms may occur.

Use in pregnancy only if benefits outweigh risks. Fetal abnormalities observed in animal studies. Avoid during lactation – potential milk excretion.

Facial application: Limit to 5 days to prevent atrophy. Monitor psoriasis patients closely. Avoid eye contact. Discontinue and start antibiotics if infection develops.

Pediatrics: Risk of adrenal suppression. Geriatric: Caution in hepatic/renal impairment. Pregnancy: Limited data; medical supervision required.

Acute overdosage is very unlikely to occur, however, in the case of chronic over-dosage or misuse the features of hypercortisolism may occur and in this situation topical steroid should be discontinued.