Acos Powder for Suspension 200 mg/5 ml

Acos Suspension is an azalide antibiotic containing Azithromycin Dihydrate (200 mg/5 ml) manufactured by Radiant Pharmaceuticals Ltd. Priced at ৳190.00 per unit, this powder for suspension treats respiratory, skin, and urogenital infections caused by susceptible microorganisms.

The medication inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It is prescribed for bronchitis, pneumonia, otitis media, and Chlamydia trachomatis infections. Adults take 500 mg daily for 3 days, while pediatric doses depend on weight (10 mg/kg). Avoid concurrent use with ergot alkaloids or cyclosporine.

Common side effects include nausea, diarrhea, and abdominal pain. Classified as pregnancy category B, it should be used cautiously during lactation. Store in a dry place away from light. For alternatives, explore Azithromycin brands like Acos 250 mg or 500 mg tablets.

Adults: 500mg OD for 3 days or 500mg+250mg for 5 days. Pediatrics (15-25kg): 10mg/kg for 3 days. Prepare powder for suspension with water, administer 1hr before/after food. Typhoid requires 7-10 days treatment. No dose adjustment in renal impairment.

Acos is well tolerated with a low incidence of side-effects. Most side-effects observed were mild to moderate in severity. The majority of side-effects were gastrointestinal in origin with nauseas, abdominal discomfort (pain/cramps), vomiting, flatulence, diarrhoea and loose stools being occasionally observed. Allergic reactions such as rash or photosensitivity have occurred and there have also been rare reports of serious hypersensitivity reactions. Reversible elevations in liver transaminases have been seen with a frequency similar to the comparative macrolides and penicillins used in clinical trials. Rarely, cases of cholestatic jaundice have been observed. Transient mild reductions in neutrofil counts have occasionally been observed in clinical trials, although a causal relationship to azithromycin has not been established. Hearing impairment: In investigational studies where higher doses were used for prolonged periods of time, reversible hearing impairment was seen in some patients.

Pregnancy Category B – use only if clearly needed. Breastfeeding not recommended due to insufficient safety data.

Monitor for superinfections. Use caution in severe renal impairment (CrCl <40ml/min). Cardiac monitoring advised in patients with arrhythmia risk factors.

Approved for pediatric use above 6 months. Geriatric patients require renal function assessment. Contraindicated in hepatic dysfunction. No dose adjustment in renal failure.

There is no data on overdosage with Acos. Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting and diarrhoea. Gastric lavage and general supportive measures are indicated.