Acos Tablet 250 mg

Acos Tablet 250 mg is a widely used macrolide antibiotic manufactured by Radiant Pharmaceuticals Ltd. Containing Azithromycin Dihydrate as its active ingredient, this tablet effectively treats respiratory, skin, and sexually transmitted infections. Each tablet delivers 250 mg strength, making it suitable for both adults and children over 6 months.

Priced at ৳30.00 per unit, Acos Tablet offers affordable therapy with a strip of 6 tablets costing ৳180.00. Its cost-effectiveness and broad-spectrum action make it a preferred choice for bacterial infections like bronchitis, pneumonia, and typhoid fever.

Indications: Acos Tablet targets infections caused by susceptible organisms, including:

• Upper/lower respiratory tract infections (sinusitis, pharyngitis)
• Skin and soft tissue infections
• Chlamydia trachomatis infections
• Otitis media and typhoid fever

The drug inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. This mechanism ensures rapid bacteriostatic action against Gram-positive and Gram-negative pathogens.

Dosage Guidelines:

• Adults: 500 mg once daily for 3 days or 500 mg followed by 250 mg for 4 days
• Children: Weight-based dosing (10 mg/kg) for 3 days

Common side effects include nausea, abdominal discomfort, and headache. Avoid concurrent use with ergot alkaloids or antacids. Although pregnancy category B, consult physicians before use during lactation.

Adults: 500 mg daily for 3 days or 500 mg day 1 followed by 250 mg for 4 days. Children (15-25 kg): 10 mg/kg daily for 3 days. Typhoid fever requires 7-10 days treatment. Tablets should be taken on empty stomach or 1 hour after meals.

Acos is well tolerated with a low incidence of side-effects. Most side-effects observed were mild to moderate in severity. The majority of side-effects were gastrointestinal in origin with nauseas, abdominal discomfort (pain/cramps), vomiting, flatulence, diarrhoea and loose stools being occasionally observed. Allergic reactions such as rash or photosensitivity have occurred and there have also been rare reports of serious hypersensitivity reactions. Reversible elevations in liver transaminases have been seen with a frequency similar to the comparative macrolides and penicillins used in clinical trials. Rarely, cases of cholestatic jaundice have been observed. Transient mild reductions in neutrofil counts have occasionally been observed in clinical trials, although a causal relationship to azithromycin has not been established. Hearing impairment: In investigational studies where higher doses were used for prolonged periods of time, reversible hearing impairment was seen in some patients.

Pregnancy Category B: No risk in animal studies but human data limited. Breastfeeding not recommended. Radiant Pharmaceuticals advises risk-benefit analysis before use.

Monitor for superinfections during prolonged use. Dose adjustment needed in renal impairment. Cardiac patients require electrolyte monitoring. Discontinue if pseudomembranous colitis suspected.

Pediatrics: Safe above 6 months age. Geriatric: Monitor liver/kidney function. Renal impairment: Caution if CrCl <40 ml/min. Hepatic disease: Absolutely contraindicated.

There is no data on overdosage with Acos. Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting and diarrhoea. Gastric lavage and general supportive measures are indicated.