Acos Tablet 500 mg

Acos Tablet is a trusted macrolide antibiotic containing Azithromycin Dihydrate 500 mg. Manufactured by Radiant Pharmaceuticals Ltd, it effectively treats respiratory infections, skin disorders, and sexually transmitted diseases. Priced at ৳55.17 per unit, the strip costs ৳165.50 (3 tablets), making it accessible for short-course therapies.

This tablet formulation inhibits bacterial protein synthesis by binding to 50S ribosomal subunits. Doctors prescribe Acos Tablet for bronchitis, pneumonia, typhoid, and uncomplicated chlamydia. Its 3-day dosage regimen (500 mg daily) enhances patient compliance compared to longer antibiotic courses.

Key dosage guidelines:

• Adults: 500 mg once daily for 3 days OR 500 mg Day 1 + 250 mg Days 2-5
• Children (15-45 kg): Weight-based 10 mg/kg for 3 days
• Typhoid: 500 mg daily for 7-10 days

While generally well-tolerated, some users report nausea or diarrhea. Avoid concurrent use with ergot alkaloids and antacids. Store in cool, dry conditions as per the manufacturer’s guidelines. Pregnant/nursing women should consult doctors despite its Category B safety profile.

Adults: 500mg once daily for 3 days OR 500mg day 1 followed by 250mg days 2-5. Children (15-25kg): 10mg/kg/day for 3 days. Typhoid: 500mg for 7-10 days. Administer 1 hour before/after food. Renal impairment requires dosage adjustment.

Acos is well tolerated with a low incidence of side-effects. Most side-effects observed were mild to moderate in severity. The majority of side-effects were gastrointestinal in origin with nauseas, abdominal discomfort (pain/cramps), vomiting, flatulence, diarrhoea and loose stools being occasionally observed. Allergic reactions such as rash or photosensitivity have occurred and there have also been rare reports of serious hypersensitivity reactions. Reversible elevations in liver transaminases have been seen with a frequency similar to the comparative macrolides and penicillins used in clinical trials. Rarely, cases of cholestatic jaundice have been observed. Transient mild reductions in neutrofil counts have occasionally been observed in clinical trials, although a causal relationship to azithromycin has not been established. Hearing impairment: In investigational studies where higher doses were used for prolonged periods of time, reversible hearing impairment was seen in some patients.

Pregnancy Category B. Use only if clearly needed. Breastfeeding safety unknown. Consult physician for risk-benefit analysis.

Monitor hepatic/renal functions during prolonged use. Initiate antifungal therapy if superinfection occurs. Rehydration essential for antibiotic-associated diarrhea.

Renal impairment (CrCl <40 ml/min): Use with caution. Hepatic disease: Contraindicated. Elderly: Dose adjustment may required. Pediatrics: Safe above 6 months.

There is no data on overdosage with Acos. Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting and diarrhoea. Gastric lavage and general supportive measures are indicated.