ডরমিটল আইএম/আইভি ইনজেকশন ১৫ মিলিগ্রাম/৩ মিলিলিটার

Dormitol IM/IV Injection

Generic Name: Midazolam

Strength: 15 mg/3 ml

Dosage Form: IM/IV Injection

Manufacturer: Square Pharmaceuticals PLC

Indications

Dormitol is indicated in-

• Short-term treatment of insomnia.
• Sedation in premedication before surgical or diagnostic procedures.

Pharmacology

The actions of benzodiazepines such as midazolam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which is one of the major inhibitory neurotransmitters in the central nervous system. Benzodiazepines increase the activity of GABA, thereby producing a sedating effect, relaxing skeletal muscles, and inducing sleep, anesthesia, and amnesia. Benzodiazepines bind to the benzodiazepine site on GABA-A receptors, which potentiates the effects of GABA by increasing the frequency of chloride channel opening. These receptors have been identified in different body tissues including the heart and skeletal muscle, although mainly appear to be present in the central nervous system.

Dosage Information

Oral dosage:

• For adults: 7.5-15 mg daily.
• In elderly and debilitated patients: The recommended dose is 7.5 mg.
• In premedication: 15 mg of Midazolam should be given 30-60 minutes before the procedure.

Intravenous administration:

• Endoscopic or Cardiovascular Procedures: In healthy adults, the initial dose is approximately 2.5 mg. In cases of severe illness and in elderly patients, the initial dose must be reduced to 1 to 1.5 mg.
• Induction of Anesthesia: The dose is 10-15 mg.

Intramuscular administration:

• Adult: 0.07-0.1 mg/kg body weight. The usual dose is about 5 mg.
• Children: 0.15-0.20 mg/kg
• Elderly and debilitated patients: 0.025-0.05 mg/kg

Rectal administration in children:

• For preoperative sedation: Rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min. before induction of general anesthesia.

Side Effects

At the start of therapy, drowsiness during daytime, confusion, fatigue, headache and muscle weakness may occur which usually disappear with repeated administration. Following parenteral (IV or IM) administration of Dormitol, fluctuations in vital signs have been noted including respiratory depression, apnea, variations in blood pressure and pulse rate.

Precautions

Dormitol IV should be administered very slowly.

প্রাপ্তবয়স্কদের জন্য IV ডোজ: এন্ডোস্কোপিতে ২.৫ mg, বৃদ্ধদের ১-১.৫ mg। IM ইনজেকশনে ০.০৭-০.১ mg/kg। শিশুদের প্রি-অপারেটিভ সেডেশনে রেক্টাল ডোজ ০.৩৫-০.৪৫ mg/kg। লিভার রোগে ডোজ ৫০% কমাতে হবে।

At the start of therapy, drowsiness during daytime, confusion, fatigue, headache and muscle weakness may occur which usually disappear with repeated administration. Following parenteral (IV or IM) administration of Dormitol, fluctuations in vital signs have been noted including respiratory depression, apnea, variations in blood pressure and pulse rate.

গর্ভাবস্থায় শুধুমাত্র জরুরি অবস্থায় ব্যবহার করুন। স্তন্যদানকালে নিষেধ, কারণ দুধের মাধ্যমে শিশুতে যায়।

অপূর্ণ শ্বাসতন্ত্র, স্থুলকায় রোগী ও বয়স্কদের ক্ষেত্রে অক্সিজেন সরবরাহ রাখুন। IV ইনজেকশন সর্বদা ধীরে দিতে হবে (১ mg/মিনিট)।

শিশুদের রেক্টাল ডোজ: ০.৩৫-০.৪৫ mg/kg। বৃদ্ধ ও লিভার রোগে ডোজ অর্ধেক করুন। কিডনি রোগে ডোজ সামঞ্জস্য প্রয়োজন।

Extreme overdosage may lead to coma, areflexia, cardiorespiratory depression and apnea. The effects of overdosage can be controlled with benzodiazepine antagonist flumazenil.