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Dormitol IM/IV Injection 15 mg/3 ml

Storage: Protect from light and moisture, store in cool and dry place. Keep out of children's reach.

ডরমিটল আইএম/আইভি ইনজেকশন Price Information

Per Piece

৳120.37

Note: Prices may vary. Contact pharmacy for latest prices.

Description

Dormitol IM/IV Injection

Generic Name: Midazolam

Strength: 15 mg/3 ml

Dosage Form: IM/IV Injection

Manufacturer: Square Pharmaceuticals PLC

Indications

Dormitol is indicated in-

  • Short-term treatment of insomnia.
  • Sedation in premedication before surgical or diagnostic procedures.

Pharmacology

The actions of benzodiazepines such as midazolam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which is one of the major inhibitory neurotransmitters in the central nervous system. Benzodiazepines increase the activity of GABA, thereby producing a sedating effect, relaxing skeletal muscles, and inducing sleep, anesthesia, and amnesia. Benzodiazepines bind to the benzodiazepine site on GABA-A receptors, which potentiates the effects of GABA by increasing the frequency of chloride channel opening. These receptors have been identified in different body tissues including the heart and skeletal muscle, although mainly appear to be present in the central nervous system.

Dosage Information

Oral dosage:

  • For adults: 7.5-15 mg daily.
  • In elderly and debilitated patients: The recommended dose is 7.5 mg.
  • In premedication: 15 mg of Midazolam should be given 30-60 minutes before the procedure.

Intravenous administration:

  • Endoscopic or Cardiovascular Procedures: In healthy adults, the initial dose is approximately 2.5 mg. In cases of severe illness and in elderly patients, the initial dose must be reduced to 1 to 1.5 mg.
  • Induction of Anesthesia: The dose is 10-15 mg.

Intramuscular administration:

  • Adult: 0.07-0.1 mg/kg body weight. The usual dose is about 5 mg.
  • Children: 0.15-0.20 mg/kg
  • Elderly and debilitated patients: 0.025-0.05 mg/kg

Rectal administration in children:

  • For preoperative sedation: Rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min. before induction of general anesthesia.

Side Effects

At the start of therapy, drowsiness during daytime, confusion, fatigue, headache and muscle weakness may occur which usually disappear with repeated administration. Following parenteral (IV or IM) administration of Dormitol, fluctuations in vital signs have been noted including respiratory depression, apnea, variations in blood pressure and pulse rate.

Precautions

Dormitol IV should be administered very slowly.

Dosage & Administration

Adults: IV 2.5 mg for endoscopy, elderly 1-1.5 mg. IM 0.07-0.1 mg/kg. Children’s rectal dose 0.35-0.45 mg/kg pre-op. Reduce dose by 50% in hepatic impairment.

Side Effects

At the start of therapy, drowsiness during daytime, confusion, fatigue, headache and muscle weakness may occur which usually disappear with repeated administration. Following parenteral (IV or IM) administration of Dormitol, fluctuations in vital signs have been noted including respiratory depression, apnea, variations in blood pressure and pulse rate.

Pregnancy & Lactation

Pregnancy Category D. Avoid during lactation – excreted in breast milk.

Precautions & Warnings

Monitor respiratory status in obese/elderly patients. Administer IV slowly (1 mg/min) with resuscitation equipment available.

Use in Special Populations

Pediatric rectal dose: 0.35-0.45 mg/kg. Reduce dose by 50% in hepatic impairment. Renal disease requires dose adjustment.

Overdose Effects

Extreme overdosage may lead to coma, areflexia, cardiorespiratory depression and apnea. The effects of overdosage can be controlled with benzodiazepine antagonist flumazenil.

ডরমিটল আইএম/আইভি ইনজেকশন Frequently Asked Questions

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Related Medicines with Midazolam

No related medicines found with the same generic.

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