Motigut Tablet 10 mg

Motigut (Domperidone Maleate 10 mg) is a prokinetic medicine manufactured by Square Pharmaceuticals PLC. This tablet effectively manages upper digestive disorders, nausea, and vomiting. Priced at ৳4.00 per unit (৳40.00 per strip), it accelerates gastric emptying by blocking dopamine receptors in the gut.

Indications include dyspeptic symptoms (bloating, heartburn), migraine-induced vomiting, and Parkinson’s disease-related nausea. Its unique mechanism minimizes neurological side effects. Dosage varies from 10-20 mg every 6-8 hours for adults. Avoid exceeding 12 weeks of continuous use. Store below 30°C away from moisture.

Key pharmacological action involves enhancing gastric motility without crossing the blood-brain barrier. This reduces risks of CNS-related adverse effects. Common side effects (<1-2%) include dry mouth, headache, and mild skin reactions. Not recommended during pregnancy; safe for lactating mothers with minimal milk transfer.

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Adults: 10-20 mg 3-4 times daily (15-30 mins before meals). Pediatric dose: 0.2-0.8 mg/kg body weight. Reduce dose by 50% in hepatic impairment. Maximum 12 weeks for acute vomiting. Swallow tablets whole with water.

Side-effects are rare; exceptionally some transient intestinal cramps have been reported. Extrapyramidal phenomena are rare in young children and exceptional in adults: they reverse spontaneously and completely as soon as the treatment is stopped. As the pituitary gland is located outside the blood-brain barrier, domperidone may induce an increase in the plasma prolactin level. In rare case this hyperprolactinaemia may give rise to neuroendocrinological phenomena such as galactorrhoea and gynaecomastia. When the blood-brain barrier is immature (as in infants) or impaired, the possible occurrence of neurological side-effects cannot be totally excluded. Rare allergic reactions, such as rash and urticaria, have also been reported.

Pregnancy Category: Not approved (risk unknown). Lactation: Low secretion in milk (0.1% maternal dose). May stimulate lactation but considered compatible with breastfeeding.

Monitor ECG in patients with cardiac history. Perform LFTs every 3 months in hepatic impairment. Discontinue if diarrhea persists >48 hrs. Assess electrolyte balance during prolonged use.

Pediatrics: Avoid in neonates <1 month. Geriatrics: Reduce dose by 25%. Hepatic impairment: Max 10 mg twice daily. Renal failure (CrCl <30 mL/min): Double dosing interval.

Symptoms of overdosage may include drowsiness, disorientation and extrapyramidal reactions, especially in children. In case of overdosage, the administration of activated charcoal, and close observation of the patients are recommended. Anticholinergic, antiparkinson drugs or antihistamines with anticholinergic properties may be helpful in controlling the extrapyramidal reactions.