Motil Oral Suspension 5 mg/5 ml

Motil Oral Suspension is a gastrointestinal medication containing Domperidone Maleate (5 mg/5 ml) manufactured by Hallmark Pharmaceuticals Ltd. Priced at ৳28.00 per unit, this oral suspension addresses digestive disorders like dyspepsia, nausea, and gastroparesis by enhancing gastric motility.

The drug works as a dopamine antagonist, accelerating stomach emptying and reducing reflux. It’s prescribed for acid reflux, migraine-induced vomiting, and Parkinson’s disease-related nausea. Dosage varies: adults take 10-20 ml every 6-8 hours, while pediatric doses depend on body weight. Always consume 15-30 minutes before meals.

Common side effects include dry mouth (1.9%), headaches (1.2%), and mild diarrhea. Rare neurological reactions may occur. Avoid combining with opioids or anticholinergics, as they reduce efficacy. Not recommended during pregnancy, though breastfeeding is considered safe due to minimal milk transfer.

Store below 30°C, shielded from moisture and light. As a prokinetic drug, Motil improves upper GI function without crossing the blood-brain barrier significantly, minimizing neurological risks. For alternatives like Motil 10 mg, consult healthcare providers for dosage adjustments.

Adults: 10-20 mg (10-20 ml) 3-4 times daily; Pediatrics: 0.2-0.4 mg/kg every 6-8 hours. Max 12 weeks for nausea. Take 15-30 mins before meals. Dose adjustment needed in hepatic/renal impairment.

Side-effects are rare; exceptionally some transient intestinal cramps have been reported. Extrapyramidal phenomena are rare in young children and exceptional in adults: they reverse spontaneously and completely as soon as the treatment is stopped. As the pituitary gland is located outside the blood-brain barrier, domperidone may induce an increase in the plasma prolactin level. In rare case this hyperprolactinaemia may give rise to neuroendocrinological phenomena such as galactorrhoea and gynaecomastia. When the blood-brain barrier is immature (as in infants) or impaired, the possible occurrence of neurological side-effects cannot be totally excluded. Rare allergic reactions, such as rash and urticaria, have also been reported.

Contraindicated in pregnancy. Compatible with lactation – minimal milk excretion. Enhances milk production via prolactin stimulation.

Monitor infants for neurological effects. Reduce frequency in hepatic impairment. Long-term use requires cardiac monitoring.

Pediatrics: Caution under 1 year. Geriatrics: Adjust dose per renal function. Hepatic impairment: Max 10 mg/day. Severe renal failure: Extend dosing intervals.

Symptoms of overdosage may include drowsiness, disorientation and extrapyramidal reactions, especially in children. In case of overdosage, the administration of activated charcoal, and close observation of the patients are recommended. Anticholinergic, antiparkinson drugs or antihistamines with anticholinergic properties may be helpful in controlling the extrapyramidal reactions.