Motilex Tablet 10 mg

Motilex Tablet is a gastrointestinal medication containing Domperidone Maleate (10 mg) manufactured by Techno Drugs Ltd. Priced at ৳3.00 per unit (strip: ৳30.00), this tablet formulation effectively manages digestive disorders and nausea.

Primarily prescribed for dyspeptic symptoms like bloating, acid reflux, and delayed gastric emptying, Motilex Tablet accelerates stomach emptying by blocking dopamine receptors. It shows minimal central nervous system effects due to poor blood-brain barrier penetration, making it safer than similar antiemetics.

The dosage varies by condition:

• Adults: 10-20 mg every 6-8 hours
• Children: Weight-adjusted liquid formulations

Take 15-30 minutes before meals for optimal efficacy. Maximum treatment duration is 12 weeks for acute nausea.

Common side effects (<1-2% incidence) include dry mouth, headaches, and mild lactation changes. Store below 30°C, protected from moisture. Avoid concurrent use with opioid analgesics or MAO inhibitors due to interaction risks.

As a cost-effective prokinetic drug, Motilex Tablet serves as a key therapy for migraine-associated vomiting and Parkinson’s medication-induced nausea. Pregnant women should consult doctors before use, though animal studies show no teratogenic effects.

Adults: 10-20 mg every 6-8 hours before meals. Pediatric dose: 0.2-0.4 mg/kg. Hepatic impairment requires dose reduction. Maximum treatment duration 12 weeks.

Side-effects are rare; exceptionally some transient intestinal cramps have been reported. Extrapyramidal phenomena are rare in young children and exceptional in adults: they reverse spontaneously and completely as soon as the treatment is stopped. As the pituitary gland is located outside the blood-brain barrier, domperidone may induce an increase in the plasma prolactin level. In rare case this hyperprolactinaemia may give rise to neuroendocrinological phenomena such as galactorrhoea and gynaecomastia. When the blood-brain barrier is immature (as in infants) or impaired, the possible occurrence of neurological side-effects cannot be totally excluded. Rare allergic reactions, such as rash and urticaria, have also been reported.

Pregnancy safety unestablished. Compatible with lactation due to minimal milk transfer.

Monitor neurological effects in infants <1 year. Regular liver function tests recommended.

Pediatrics: Caution due to immature BBB. Renal impairment: Reduce dose to 1-2 times daily if creatinine >6 mg/dl.

Symptoms of overdosage may include drowsiness, disorientation and extrapyramidal reactions, especially in children. In case of overdosage, the administration of activated charcoal, and close observation of the patients are recommended. Anticholinergic, antiparkinson drugs or antihistamines with anticholinergic properties may be helpful in controlling the extrapyramidal reactions.