Motinorm Tablet 10 mg

Motinorm, containing Domperidone Maleate 10 mg, is a prokinetic medication manufactured by Sharif Pharmaceuticals Ltd. Primarily used for gastrointestinal disorders, it addresses delayed gastric emptying, acid reflux, and nausea. Available as affordable tablets (৳2.00/unit), Motinorm accelerates digestion and relieves dyspeptic symptoms effectively.

This dopamine antagonist strengthens lower esophageal sphincter pressure and enhances gastric motility. Unlike similar drugs, it minimally crosses the blood-brain barrier, reducing neurological side effects. Clinical studies show efficacy in managing migraine-associated vomiting and Parkinson’s medication-induced nausea. The strip price (৳20.00) and bulk pack (৳200.00) make it cost-effective for chronic users.

Key indications include:

• Upper abdominal bloating and postprandial discomfort
• GERD-related heartburn and regurgitation
• Acute nausea from infections or radiotherapy
• Barium meal acceleration in diagnostic imaging

Dosage varies by age: Adults take 10-20 mg every 6-8 hours before meals. Pediatric doses use weight-based suspensions. Storage requires protection from moisture and temperatures below 30°C. Common side effects (<1-2%) include dry mouth and transient headaches. Contraindicated with MAO inhibitors due to interaction risks.

Adults: 10-20 mg 3-4 times daily (15-30 mins before meals). Pediatric dose: 0.2-0.4 mg/kg body weight TDS. Maximum treatment duration for acute vomiting: 12 weeks. Dose adjustment required in hepatic/renal impairment. Tablets should be taken on empty stomach unless advised otherwise.

Side-effects are rare; exceptionally some transient intestinal cramps have been reported. Extrapyramidal phenomena are rare in young children and exceptional in adults: they reverse spontaneously and completely as soon as the treatment is stopped. As the pituitary gland is located outside the blood-brain barrier, domperidone may induce an increase in the plasma prolactin level. In rare case this hyperprolactinaemia may give rise to neuroendocrinological phenomena such as galactorrhoea and gynaecomastia. When the blood-brain barrier is immature (as in infants) or impaired, the possible occurrence of neurological side-effects cannot be totally excluded. Rare allergic reactions, such as rash and urticaria, have also been reported.

Pregnancy safety unconfirmed—use only if benefits outweigh risks. Excreted minimally in breast milk; consult physician. No teratogenic effects observed in animal studies.

Monitor infants for extrapyramidal symptoms. Reduce dose in hepatic impairment. ECG monitoring advised during prolonged use. Discontinue if cardiac arrhythmia occurs.

Pediatrics: Avoid in neonates <12 months. Elderly: Adjust dose based on renal function. Hepatic impairment: Limit to 10 mg/day. Renal failure: Reduce dosing frequency.

Symptoms of overdosage may include drowsiness, disorientation and extrapyramidal reactions, especially in children. In case of overdosage, the administration of activated charcoal, and close observation of the patients are recommended. Anticholinergic, antiparkinson drugs or antihistamines with anticholinergic properties may be helpful in controlling the extrapyramidal reactions.