Unipril Tablet 5 mg

Unipril Tablet is a cardiovascular medication containing Ramipril (5 mg) manufactured by ACME Laboratories Ltd. Priced at ৳8.07 per unit, this tablet formulation effectively manages hypertension, heart failure, and post-heart attack care while reducing cardiovascular risks.

As an ACE inhibitor, Unipril blocks angiotensin II production, lowering blood pressure and improving cardiac function. Its therapeutic benefits extend to diabetic nephropathy management. The drug’s long-acting nature makes it suitable for chronic use, though dosage adjustments are necessary for renal-impaired patients.

Key indications include:

• Primary or combination therapy for high blood pressure
• Heart failure management post-myocardial infarction
• Prevention of stroke and cardiovascular death in high-risk patients

The dosage regimen varies from 1.25–20 mg daily based on condition severity. Notable precautions include avoiding NSAIDs and potassium supplements. Common side effects like dizziness (10–15% cases) and dry cough (2–5%) typically resolve with continued use, though rare angioedema requires immediate discontinuation.

Priced affordably at ৳242.10 for 30 tablets, Unipril offers cost-effective cardiovascular protection. Store below 30°C and consult physicians for personalized dosing. Explore other Ramipril brands like Unipril 1.25 mg/2.5 mg for flexible treatment options.

Initial adult dose: 1.25-2.5 mg once daily, max 20 mg/day. Renal impairment starts with 1.25 mg. Post-MI therapy: 2.5 mg twice daily. Administer empty stomach or with food. Gradually titrate dose every 2 weeks. Do not discontinue abruptly without medical supervision.

Unipril is generally well tolerated. Dizziness, headache, fatigue and asthenia are commonly reported side effects. Other side effects occurring less frequently include symptomatic hypotension, cough, nausea, vomiting, diarrhoea, rash, urticaria, oliguria, anxiety, amnesia etc. Angioneurotic oedema, anaphylactic reactions and hyperkalaemia have also been reported rarely.

Pregnancy Category D. Contraindicated in lactation. Discontinue immediately if pregnancy occurs. Alternative antihypertensives recommended for breastfeeding mothers.

Monitor blood pressure, renal function, electrolytes regularly. Use caution in volume-depleted patients. Avoid rapid dose escalation in elderly. ACME Laboratories Ltd recommends baseline renal tests before therapy.

Geriatric: Start with 1.25 mg. Renal impairment: Max 5 mg/day if CrCl <20 ml/min. Hepatic dysfunction: Max 2.5 mg/day. Not approved for pediatric use. Tablet formulation requires adjustment in special populations.

Sign and symptom: Overdosage may cause excessive peripheral vasodilatation (with marked hypotension, shock), bradycardia, electrolyte disturbances, and renal failure.

Management: Primary detoxifcation by, for example, gastric lavage, administration of adsorbents, sodium sulfate; (if possible during the frst 30 minutes). In the event of hypotension administration of α1-adrenergic agonists (e.g. norepinephrine, dopamine) or angiotensin II (angiotensinamide), which is usually available only in scattered research laboratories, must be considered in addition to volume and salt substitution.